The Penicillin Cocktail Is A Prescription For Fun

May 31, 2026 | By Benjamin Smith
Penicillin

Everything You Need to Know About Penicillin

The Penicillin is a modern classic, a smoky and spicy balm for the soul that emerged from the vibrant New York City cocktail scene in the mid-2000s, specifically from the talented bartender Sam Ross at Milk & Honey. In the same wheelhouse as The Gold Rush, it quickly became a favorite, lauded for its unique balance of smokey Scotch, bright citrus, warming ginger-honey notes, and floating Islay Single Malt. Much like its pharmaceutical namesake, this cocktail is often humorously suggested as a "cure-all," perfect for a cozy night in, a sophisticated gathering, or when you simply need a delicious pick-me-up.

Penicillin

Prep Time3 min
Yield1 Cocktail
Base SpiritScotch Whisky

Ingredients

  • 2 oz Blended Scotch
  • 0.75 oz Fresh Lemon Juice
  • 0.75 oz Honey-Ginger Syrup
  • 0.25 oz Islay Single Malt Scotch (for float)
  • Candied Ginger, for garnish
The Penicillin Cocktail Is A Prescription For Fun

Instructions

  1. Combine blended Scotch, fresh lemon juice, and honey-ginger syrup in a shaker with ice.
  2. Shake vigorously until thoroughly chilled, about 15-20 seconds.
  3. Double strain into a chilled rocks glass filled with a large, fresh ice cube.
  4. Gently float the single malt Scotch over the top by slowly pouring it over the back of a spoon.
  5. Garnish with candied ginger.
Pro Tip
For the best Penicillin, ensure your honey-ginger syrup is freshly made for optimal flavor. The Islay Scotch float is crucial for the drink's signature smoky aroma and depth. Don't skip the double strain to ensure a smooth, pulp-free cocktail.

Penicillin Riff

A common riff is to experiment with different types of honey or ginger to subtly alter the syrup's profile, or to use a smoked or peated honey in the syrup itself for an even more intense smoky character.

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